IMMUNOLOGY2026™ Conference Recordings For Attendees-Multimodal Immune Profiling in Thyroid Eye Disease

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Video Summary

The speaker, a PhD student and ophthalmology resident, presented multimodal immune profiling of thyroid eye disease (TED). TED is an autoimmune orbital disorder causing proptosis, diplopia, pain, and sometimes optic neuropathy, with limited, often nonspecific treatments. Using orbital tissue from active and inactive TED patients plus blood samples, the team performed single-cell RNA sequencing and immune receptor profiling. They found distinct fibroblast and macrophage subtypes linked to disease stage, along with T-cell activation and clonal expansion, especially in active disease. The findings suggest TED is driven by dynamic cellular programs, supporting earlier, stage-specific targeted therapies rather than reactive treatment.

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Date April 19, 2026 9:45 AM - 10:00 AM

Room 153 AB

Session Primary Immune Deficiency and Immune Dysregulation

Speaker Anne Xuan-Lan Nguyen

Track Immune Mechanisms of Human Disease (HUM)

Year 2026

Keywords

thyroid eye disease

single-cell RNA sequencing

immune profiling

orbital fibroblasts

T-cell activation

April 19, 2026 9:45 AM - 10:00 AM

153 AB

Primary Immune Deficiency and Immune Dysregulation

Anne Xuan-Lan Nguyen

Immune Mechanisms of Human Disease (HUM)

2026