IMMUNOLOGY2026™ Conference Recordings For Attendees-Myeloid STAT4 at the Intersection of Sleep Disruption and Hyperlipidemia: A Molecular Link Between Lifestyle Stress and Atherogenesis

Myeloid STAT4 at the Intersection of Sleep Disruption and Hyperlipidemia: A Molecular Link Between Lifestyle Stress and Atherogenesis

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Video Summary

Elena Moriarty described research linking sleep fragmentation to atherosclerosis. In ApoE mice on a high-fat diet, interrupted sleep increased aortic plaque formation and made plaques less stable, with more necrotic cores and less collagen. Sleep fragmentation also activated neutrophils, boosting ROS, degranulation, and NETosis, and promoted their recruitment to the aorta. Neutrophil depletion reduced plaque burden, but a more targeted STAT4 deletion lowered lesion formation and neutrophil activation while unexpectedly increasing mortality, possibly due to intestinal oxidative stress, leaky gut, and circulating LPS. The team is now investigating gut infection and barrier dysfunction as possible causes.

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Date April 18, 2026 8:30 AM - 8:45 AM

Room 104AB

Session Tissue and Mucosal Immunity

Speaker Alina Moriarty

Track Immune Mechanisms of Human Disease (HUM)

Year 2026

Keywords

sleep fragmentation

atherosclerosis

neutrophils

ApoE mice

STAT4

April 18, 2026 8:30 AM - 8:45 AM

104AB

Tissue and Mucosal Immunity

Alina Moriarty

Immune Mechanisms of Human Disease (HUM)

2026