IMMUNOLOGY2026™ Conference Recordings For Attendees-Myeloid-specific NLRP12 is a checkpoint of colonic inflammation by promoting taurine-driven microbiota

Myeloid-specific NLRP12 is a checkpoint of colonic inflammation by promoting taurine-driven microbiota

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Video Summary

The talk focused on NLRP12, an understudied NLR family protein that regulates inflammation. The speaker showed that NLRP12 is highly expressed in myeloid cells and has a protective role in DSS-induced colitis. Using myeloid-specific knockout mice, they found increased weight loss, disease severity, colon shortening, immune infiltration, and activation of inflammatory pathways, while epithelial-specific deletion had little effect. Microbiome analysis revealed reduced diversity, loss of beneficial bacteria, and expansion of harmful taxa in myeloid NLRP12-deficient mice. These microbial changes matched patterns seen in ulcerative colitis patients. The team also showed that the harmful bacterium Allobaculum worsened colitis in germ-free mice. Finally, they identified taurine as a reduced metabolite in knockout mice; taurine supplementation improved colitis and shifted the microbiota toward beneficial bacteria. Overall, myeloid NLRP12 appears to maintain gut health by limiting inflammation, preserving microbiota balance, and supporting taurine-associated protection.

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Date April 16, 2026 11:00 AM - 11:15 AM

Room 102

Session Innate Immune Defenses in the Epithelium

Speaker Guannan Huang

Track Innate Immune Responses and Host Defense: Cellular Mechanisms (INC)

Year 2026

Keywords

NLRP12

myeloid cells

DSS-induced colitis

gut microbiota

taurine supplementation

inflammation regulation

April 16, 2026 11:00 AM - 11:15 AM

102

Innate Immune Defenses in the Epithelium

Guannan Huang

Innate Immune Responses and Host Defense: Cellular Mechanisms (INC)

2026