IMMUNOLOGY2026™ Conference Recordings For Attendees-NLRP3 confers regulatory T cell-mediated control of intestinal inflammation

NLRP3 confers regulatory T cell-mediated control of intestinal inflammation

Video Transcription

Video Summary

The speaker, a UCSD PhD student, described research on an unexpected anti-inflammatory role for NLRP3 in regulatory T cells (Tregs). In intestinal inflammation and colon cancer models, Tregs upregulated NLRP3, and Treg-specific NLRP3 deletion led to stronger Th17 responses, more IL-17 production, worse colitis, shortened colons, and more tumors. Mechanistically, RNA-seq and follow-up experiments showed that NLRP3 promotes IL-1R2 expression in Tregs. Tregs can secrete IL-1R2, which acts as a decoy receptor to block IL-1 signaling, thereby reducing Th17 activation and IL-17 output. The proposed model is that Treg NLRP3 induces IL-1 beta signaling within Tregs, which increases IL-1R2 and helps suppress intestinal inflammation. The talk highlighted that inflammasome components can have anti-inflammatory functions in adaptive immune cells, not just pro-inflammatory roles in myeloid cells.

Meta Tag

Date April 17, 2026 10:00 AM - 10:15 AM

Room 156

Session New Paradigms in T Cell Regulation

Speaker Rasika Patkar

Track Immune Response Regulation: Cellular Mechanisms (IRC)

Year 2026

Keywords

NLRP3

regulatory T cells

IL-1R2

Th17 response

intestinal inflammation

April 17, 2026 10:00 AM - 10:15 AM

156

New Paradigms in T Cell Regulation

Rasika Patkar

Immune Response Regulation: Cellular Mechanisms (IRC)

2026