IMMUNOLOGY2026™ Conference Recordings For Attendees-Neutrophil Extracellular Traps Prime B Cell-Mediated Fibrogenesis in MASH by Silencing HES1 and Promoting Plasma Cell Differentiation

Neutrophil Extracellular Traps Prime B Cell-Mediated Fibrogenesis in MASH by Silencing HES1 and Promoting Plasma Cell Differentiation

Back to course

Video Transcription

Video Summary

The speaker described research on MASH, a severe form of fatty liver disease that can progress to fibrosis and cancer. Using a mouse model and single-cell RNA sequencing of liver immune cells, the team found that B cells undergo major transcriptomic changes during fibrosis, while neutrophils and monocytes increase. They focused on neutrophil extracellular traps (NETs), showing that NETs rise with disease severity and that blocking or digesting NETs reduces fibrosis. A key finding was that NETs suppress the B-cell regulator HACE1, likely promoting inflammation and fibrosis progression.

Meta Tag

Date April 16, 2026 1:15 PM - 1:30 PM

Room 156

Session Humoral-innate Immune Crosstalk

Speaker Hongji Zhang

Track Immune Response Regulation: Cellular Mechanisms (IRC)

Year 2026

Keywords

MASH

fibrosis

neutrophil extracellular traps

B cells

HACE1

April 16, 2026 1:15 PM - 1:30 PM

156

Humoral-innate Immune Crosstalk

Hongji Zhang

Immune Response Regulation: Cellular Mechanisms (IRC)

2026