IMMUNOLOGY2026™ Conference Recordings For Attendees-Neutrophil-derived vesicles control complement activation to facilitate inflammation resolution

Neutrophil-derived vesicles control complement activation to facilitate inflammation resolution

Video Transcription

Video Summary

The talk challenged the idea that neutrophils are only destructive immune cells. The speaker described neutrophils as fast-moving white blood cells with multiple antimicrobial functions, but also a very short lifespan. Using live imaging, the team discovered that aging neutrophils release large vesicles called LANDVs (Large Aging Neutrophil-Derived Vesicles), which appear late in neutrophil culture and even persist in inflamed tissue.<br /><br />In a bacterial pneumonia model, LANDVs reduced neutrophil recruitment, inflammatory cytokines, lung damage, and even improved survival. Their key protective molecule is CD55, a complement-regulating protein. Experiments showed that LANDV protection depends on complement inhibition and that LANDVs persist in tissues through “don’t eat me” signals. The speaker also found LANDVs in human pneumonia and COVID-19 samples, where higher levels were associated with milder disease. Overall, the work suggests aging neutrophils help resolve inflammation by producing anti-inflammatory vesicles that restore immune balance.

Meta Tag

Date April 16, 2026 12:45 PM - 1:00 PM

Room 156

Session Humoral-innate Immune Crosstalk

Speaker Alan Hsu

Track Immune Response Regulation: Cellular Mechanisms (IRC)

Year 2026

Keywords

neutrophils

LANDVs

pneumonia

complement inhibition

CD55

April 16, 2026 12:45 PM - 1:00 PM

156

Humoral-innate Immune Crosstalk

Alan Hsu

Immune Response Regulation: Cellular Mechanisms (IRC)

2026