IMMUNOLOGY2026™ Conference Recordings For Attendees-Olfactory Receptor 2 Signaling in Monocytes Facilitates Chemotactic Migration to Atherosclerotic Aorta Due to Octanal from Dysfunctional Endothelium

Olfactory Receptor 2 Signaling in Monocytes Facilitates Chemotactic Migration to Atherosclerotic Aorta Due to Octanal from Dysfunctional Endothelium

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Video Summary

The talk examined the olfactory receptor OR52/OLFAR2 on macrophages in melanoma. Although olfactory receptors are usually involved in smell, this receptor was found mainly on tumor-associated macrophages. In mouse B16F10 tumors, loss of OLFAR2 increased tumor growth, reduced macrophage infiltration and activation, and lowered cytokines and chemokines such as CCL2 and CXCL9. Knockout mice also showed weaker CD8 T-cell activation and antigen presentation, suggesting impaired anti-tumor immunity. Human melanoma data linked higher OR6A2 expression with better survival after checkpoint blockade. Overall, macrophage OLFAR2 appears to support anti-tumor immune responses.

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Date April 17, 2026 10:45 AM - 11:00 AM

Room 102

Session Lymphocyte and Innate Leukocyte Mastery of Heat, Migration, and Inflammation

Speaker Khalia Cummings

Track Cellular Adhesion, Migration, and Inflammation (CAM)

Year 2026

Keywords

OLFAR2

macrophages

melanoma

tumor immunity

checkpoint blockade

April 17, 2026 10:45 AM - 11:00 AM

102

Lymphocyte and Innate Leukocyte Mastery of Heat, Migration, and Inflammation

Khalia Cummings

Cellular Adhesion, Migration, and Inflammation (CAM)

2026