IMMUNOLOGY2026™ Conference Recordings For Attendees-Olfactory receptor 2+ tumor-associated macrophages activate CD8+ T cells to suppress tumor growth

Olfactory receptor 2+ tumor-associated macrophages activate CD8+ T cells to suppress tumor growth

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Video Summary

The thesis examined how olfactory receptor 2 (OR2) contributes to atherosclerosis. Atherosclerosis is a chronic inflammatory disease driven by plaque buildup in blood vessels. The speaker showed that OR2 expression rises with high-fat diet in mice and that its human ortholog, OR6A2, is present in monocytes within human plaques. Experiments found that octanol, OR2’s ligand, strongly promotes monocyte migration toward diseased aortic tissue. The study also suggests octanol may be produced by ferroptosis in aortic endothelial cells. Overall, OR2 and octanol appear to help recruit immune cells and worsen plaque progression.

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Date April 18, 2026 8:15 AM - 8:30 AM

Room 156

Session Tumor and Immune Cell Crosstalk

Speaker Elayne Benson

Track Tumor Immunology: Cellular Responses and Tumor Microenvironment (TIME)

Year 2026

Keywords

olfactory receptor 2

atherosclerosis

monocyte migration

octanol

ferroptosis

April 18, 2026 8:15 AM - 8:30 AM

156

Tumor and Immune Cell Crosstalk

Elayne Benson

Tumor Immunology: Cellular Responses and Tumor Microenvironment (TIME)

2026