IMMUNOLOGY2026™ Conference Recordings For Attendees-Oncostatin M Limits Lung Injury during Influenza by Modulating Leukocyte Recruitment and Inducing Tissue Repair Factors

Oncostatin M Limits Lung Injury during Influenza by Modulating Leukocyte Recruitment and Inducing Tissue Repair Factors

Video Transcription

Video Summary

The symposium introduced respiratory tract immunology, with a focus on how immune signals shape lung disease. The main talk by Yu-Wu Lee examined oncostatin M (OSM) in influenza pneumonia. OSM was found to increase in infected lungs, and OSM-deficient mice showed greater weight loss, lung injury, and altered immune cell responses, including fewer tissue-resident alveolar macrophages and more inflammatory monocytes and NK cells. Surprisingly, OSM receptor–deficient mice did not show the same worsening, suggesting OSM can protect the lung without its classic receptor. Follow-up experiments showed OSM still activated STAT3 and some protective gene programs in OSM receptor–knockout lungs. Single-cell RNA sequencing and staining suggested an alternate signaling pathway, likely involving LIF receptor on endothelial and other cells. Overall, the study suggests OSM limits pneumonia-driven inflammation and lung injury through both OSM receptor–dependent and independent mechanisms.

Meta Tag

Date April 15, 2026 2:45 PM - 3:00 PM

Room 102

Session Immunology of the Respiratory Tract

Speaker Yewoo Lee

Track Mucosal And Regional Immunology (MUC)

Year 2026

Keywords

respiratory tract immunology

oncostatin M

influenza pneumonia

lung injury

STAT3 signaling

April 15, 2026 2:45 PM - 3:00 PM

102

Immunology of the Respiratory Tract

Yewoo Lee

Mucosal And Regional Immunology (MUC)

2026