IMMUNOLOGY2026™ Conference Recordings For Attendees-Persistent IL-17 Cytokine Patterns and Th17 Expansion Characterize Chronic Critical Illness after Severe Trauma

Persistent IL-17 Cytokine Patterns and Th17 Expansion Characterize Chronic Critical Illness after Severe Trauma

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Video Summary

The talk examined trauma patients who later develop chronic critical illness (CCI), a condition usually identified only after prolonged ICU stay. By tracking blood samples from early hospitalization, researchers found that CCI patients showed early neutrophilia, reduced T-cell counts, frequent early pneumonia-type infections, and especially elevated, persistent TH17 cells and IL-17A/IFN-γ cytokines. T cells remained functionally active despite lymphopenia, suggesting immune cell redistribution rather than simple suppression. These early immune patterns may help predict which trauma patients will progress to CCI and could improve understanding of its underlying drivers.

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Date April 17, 2026 1:45 PM - 2:00 PM

Room 205

Session Interrogation of Chronic Immunity and Interventional Approaches

Speaker Caleb Kim

Track Translational and Interventional Immunology (TI)

Year 2026

Keywords

chronic critical illness

trauma patients

neutrophilia

TH17 cells

IL-17A IFN-γ

April 17, 2026 1:45 PM - 2:00 PM

205

Interrogation of Chronic Immunity and Interventional Approaches

Caleb Kim

Translational and Interventional Immunology (TI)

2026