IMMUNOLOGY2026™ Conference Recordings For Attendees-Persistent uterine inflammation following murine chorioamnionitis predisposes to poor outcomes in subsequent pregnancy

Persistent uterine inflammation following murine chorioamnionitis predisposes to poor outcomes in subsequent pregnancy

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Afichka Ezilo presented findings that choriomyonitis can cause long-lasting uterine inflammation, increasing the risk of poor outcomes in later pregnancies. Using a mouse model of ascending E. coli infection, the team showed that after recovery and re-breeding, offspring from previously infected dams had lower survival and reduced birth weight. They also found fetal growth restriction linked to abnormal placental structure, including disrupted junctional zone and labyrinth organization and increased cellularity in the decidual layer.  <br /><br />To explain these effects, the group examined the postpartum uterus. They found little evidence that persistent E. coli infection alone caused the defects, but they did see sustained immune activation: more uterine immune cells, especially T cells, activated macrophages and dendritic cells, and increased antigen-experienced CD4 and CD8 T cells. Tregs were also increased, with signs of reduced stability. Overall, the study suggests choriomyonitis leaves an inflammatory immune memory in the uterus that may impair future placentation and neonatal health.

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Date April 17, 2026 4:30 PM - 4:45 PM

Room 253

Session Regulation of Immunity and Inflammation in the Genital Tract

Speaker Ifechukwu Ezeilo

Track Mucosal And Regional Immunology (MUC)

Year 2026

Keywords

choriomyonitis

uterine inflammation

placental abnormalities

immune memory

fetal growth restriction

April 17, 2026 4:30 PM - 4:45 PM

253

Regulation of Immunity and Inflammation in the Genital Tract

Ifechukwu Ezeilo

Mucosal And Regional Immunology (MUC)

2026