IMMUNOLOGY2026™ Conference Recordings For Attendees-Pseudomonas instigates neutrophil accumulation in adipose tissue and insulin resistance in obesity

Pseudomonas instigates neutrophil accumulation in adipose tissue and insulin resistance in obesity

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Video Summary

The speaker described how obesity triggers early inflammation in adipose tissue through a gut-derived microbe, Pseudomonas. In both human samples and mouse “avatar” models fed obese microbiomes or high-fat diet, neutrophils increased first in fat tissue, followed later by T-cell shifts and macrophage activation. Pseudomonas was enriched in obese donor material, detected in adipose tissue, and could reproduce neutrophil accumulation when given alone, unlike other bacteria or bacterial components. Repeated Pseudomonas exposure also reduced insulin sensitivity without changing body weight or causing systemic infection. The proposed model is that high-fat diet causes gut dysbiosis and leakage of bacteria or products into circulation, which then reaches fat, recruits neutrophils, and contributes to later immune remodeling and insulin resistance.

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Date April 16, 2026 9:39 AM - 9:54 AM

Room Ballroom

Session Major Symposium B: Microbiome Influence on Epithelial-immune Crosstalk

Speaker Dharti Shantaram

Track Mucosal And Regional Immunology (MUC)

Year 2026

Keywords

obesity

Pseudomonas

adipose inflammation

neutrophils

insulin resistance

April 16, 2026 9:39 AM - 9:54 AM

Ballroom

Major Symposium B: Microbiome Influence on Epithelial-immune Crosstalk

Dharti Shantaram

Mucosal And Regional Immunology (MUC)

2026