IMMUNOLOGY2026™ Conference Recordings For Attendees-Ptpn22 Restricts Antiviral B cell Response by Modulating BCR Signaling

Ptpn22 Restricts Antiviral B cell Response by Modulating BCR Signaling

Video Transcription

Video Summary

Macy Proctor-Roser studies how PTPN22/PEP affects B cells during chronic LCMV infection. Using CRISPR knockout mice, she found PEP-null mice recovered weight better, cleared virus faster, and produced more anti-LCMV antibodies. Naive B-cell development was unchanged, but after infection PEP-null mice showed more plasmablasts and improved B-cell help to CD4 T cells, including greater Tfh differentiation. However, PEP did not alter SYK phosphorylation after IgM stimulation, challenging the idea that it directly brakes BCR signaling. Overall, PEP appears to shape antiviral immunity mainly through B cell–T cell interactions rather than naive B-cell development.

Meta Tag

Date April 19, 2026 8:45 AM - 9:00 AM

Room 104AB

Session CD4+ T Cell and B Cell Mediated Immunity against Viruses

Speaker Macie Proctor-Roser

Track Viral Immunology (VIR)

Year 2026

Keywords

PTPN22

PEP

B cells

LCMV infection

CRISPR knockout mice

April 19, 2026 8:45 AM - 9:00 AM

104AB

CD4+ T Cell and B Cell Mediated Immunity against Viruses

Macie Proctor-Roser

Viral Immunology (VIR)

2026