IMMUNOLOGY2026™ Conference Recordings For Attendees-RNF144A enforces IL-2-STAT5 dominance over RAF-ERK-MAPK signaling in antiviral CD8 T cells

RNF144A enforces IL-2-STAT5 dominance over RAF-ERK-MAPK signaling in antiviral CD8 T cells

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Video Summary

The speaker described how RNF144A regulates IL-2 signaling in CD8 T cells during influenza infection. Using human and mouse CD8 T cells, they found RNF144A promotes STAT5 signaling while suppressing the alternative MAPK/ARC pathway by ubiquitinating RAF1. RNF144A deficiency reduced IL-2-driven effector gene expression, weakened antiviral CD8 responses, and increased influenza susceptibility and lung damage. In patient data, low RNF144A levels correlated with severe influenza and elevated ARC-target genes. The study suggests RNF144A is both a key regulator of protective immunity and a potential biomarker for severe influenza.

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Date April 16, 2026 5:15 PM - 5:30 PM

Room 157

Session Molecular Mechanisms of T Cell Differentiation and Function

Speaker Dhaneshwar Kumar

Track Immune Response Regulation: Molecular Mechanisms (IRM)

Year 2026

Keywords

RNF144A

IL-2 signaling

CD8 T cells

influenza infection

STAT5 RAF1

April 16, 2026 5:15 PM - 5:30 PM

157

Molecular Mechanisms of T Cell Differentiation and Function

Dhaneshwar Kumar

Immune Response Regulation: Molecular Mechanisms (IRM)

2026