IMMUNOLOGY2026™ Conference Recordings For Attendees-Real-Time Single-Cell Kinetics of Innate Immune Activation

Real-Time Single-Cell Kinetics of Innate Immune Activation

Video Transcription

Video Summary

Skyler Briggs from the University of Florida/Scripps studied how three antiviral innate immune pathways—RNase L, PKR, and IRF3—interact during flavivirus infection. Using fluorescent reporter cells, knockout lines, and imaging methods, he found that IRF3 activation does not depend on RNase L, and PKR and RNase L also activate independently of IRF3 or each other during poly-IC treatment and infections with West Nile and Zika viruses. He proposes innate immunity is more like sturdy Roman columns than a house of cards: pathways are parallel and independent, so losing one weakens but does not collapse the system.

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Date April 18, 2026 1:30 PM - 1:45 PM

Room 156

Session Microenvironmental Influences on Innate Immunity

Speaker Skyler Briggs

Track Innate Immune Responses and Host Defense: Cellular Mechanisms (INC)

Year 2026

Keywords

innate immunity

RNase L

PKR

IRF3

flavivirus infection

April 18, 2026 1:30 PM - 1:45 PM

156

Microenvironmental Influences on Innate Immunity

Skyler Briggs

Innate Immune Responses and Host Defense: Cellular Mechanisms (INC)

2026