IMMUNOLOGY2026™ Conference Recordings For Attendees-Recruitment of immune cells from vascular and avascular sites to altered tissues

Recruitment of immune cells from vascular and avascular sites to altered tissues

Video Transcription

Video Summary

Paul Koops described decades of intravital microscopy studies showing how immune cells move and function inside living tissues. He began with classic work on leukocyte recruitment in vessels, then showed how neutrophils use different integrins and adhesion pathways depending on the tissue compartment. In solid organs like the liver, his lab discovered immune cells already patrolling inside sinusoids, including Kupffer cells, monocytes, and NKT cells, and showed how these cells adapt during fibrosis and injury. He highlighted chemotactic signaling, mitochondrial formyl peptides, and the surprising roles of neutrophils in clearing debris, promoting repair, and even returning to the bone marrow after injury. He also described monocyte-to-macrophage conversion during sterile injury, NKT-cell-driven IL-4 responses, and macrophage recruitment in the peritoneal cavity. Finally, he explained how mast cells release membrane-less condensates that help organize macrophages and support wound healing.

Meta Tag

Date April 18, 2026 5:17 PM - 5:45 PM

Room Ballroom

Session President's Symposium: Going Places: The Multi-Step Adhesion Cascade - 35 Years and Counting

Speaker Paul Kubes

Track Cellular Adhesion, Migration, and Inflammation (CAM)

Year 2026

Keywords

intravital microscopy

immune cell migration

neutrophil adhesion

liver sinusoids

macrophage recruitment

wound healing

April 18, 2026 5:17 PM - 5:45 PM

Ballroom

President's Symposium: Going Places: The Multi-Step Adhesion Cascade - 35 Years and Counting

Paul Kubes

Cellular Adhesion, Migration, and Inflammation (CAM)

2026