IMMUNOLOGY2026™ Conference Recordings For Attendees-Reduced BCMA Signaling Disrupts the BAFF/APRIL Axis and Promotes Inflammatory Cytokine Production by B Cells in Multiple Sclerosis.

Reduced BCMA Signaling Disrupts the BAFF/APRIL Axis and Promotes Inflammatory Cytokine Production by B Cells in Multiple Sclerosis.

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Video Summary

The speaker presents evidence that reduced BCMA signaling in B cells disrupts the BAFF/APRIL axis and promotes inflammation in multiple sclerosis (MS). MS is an autoimmune disease marked by demyelination and neurodegeneration. In patients, transitional B cells, which are anti-inflammatory, are decreased, especially during relapse, while memory B cells increase. Relapse is also associated with lower BAFF levels and reduced BCMA expression on transitional B cells. Experiments showed BAFF and APRIL can regulate IL-6 and IL-10 production, and blocking BCMA reduces APRIL-driven IL-10. Overall, impaired BCMA signaling appears to shift B cells toward a pro-inflammatory state in MS.

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Date April 16, 2026 8:30 AM - 8:45 AM

Room 156

Session Targeting B Cells and Innate Immune Functions in Autoimmunity

Speaker Gaurav Kumar

Track Therapeutic Approaches to Autoimmunity (THER)

Year 2026

Keywords

BCMA signaling

BAFF/APRIL axis

multiple sclerosis

B cells

inflammation

April 16, 2026 8:30 AM - 8:45 AM

156

Targeting B Cells and Innate Immune Functions in Autoimmunity

Gaurav Kumar

Therapeutic Approaches to Autoimmunity (THER)

2026