IMMUNOLOGY2026™ Conference Recordings For Attendees-Regulation of Inflammatory Diseases by Solute Carrier Transporters

Regulation of Inflammatory Diseases by Solute Carrier Transporters

Video Transcription

Video Summary

The talk focused on SLC46A3, a membrane transporter highly expressed in gut epithelial cells. Researchers showed it transports muramyl dipeptide (MDP), a bacterial peptidoglycan fragment, into cells where it activates NOD2 and downstream NF-kappa B inflammatory signaling. Using reporter assays, click chemistry, and NOD2 activation tests, they confirmed SLC46A3 specifically transports MDP, unlike SLC46A2, which handles NOD1 ligands. In mice, loss of SLC46A3 reduced MDP transport, lowered cytokine responses, increased gut permeability, and made animals more susceptible to DSS-induced colitis. Transfer of mutant microbiota also worsened disease, suggesting SLC46A3 helps maintain healthy gut microbial balance.

Meta Tag

Date April 17, 2026 8:45 AM - 9:00 AM

Room 156

Session Mechanisms of Innate Immunity

Speaker Ravi Bharadwaj

Track Innate Immune Responses and Host Defense: Molecular Mechanisms (INM)

Year 2026

Keywords

SLC46A3

muramyl dipeptide

NOD2 signaling

gut epithelial cells

colitis

April 17, 2026 8:45 AM - 9:00 AM

156

Mechanisms of Innate Immunity

Ravi Bharadwaj

Innate Immune Responses and Host Defense: Molecular Mechanisms (INM)

2026