IMMUNOLOGY2026™ Conference Recordings For Attendees-Regulatory B cells ameliorate experimental periodontitis through promoting macrophage-mediated pro-resolving functions

Regulatory B cells ameliorate experimental periodontitis through promoting macrophage-mediated pro-resolving functions

Video Transcription

Video Summary

The speaker, Xiao Han from Nova Southeastern University, discussed how regulatory B cells, especially B10 cells, help resolve periodontal inflammation by interacting with macrophages. B10 cells produce IL-10 and engage PD-L1/PD-1 signaling, shifting macrophages toward an anti-inflammatory M2-like state while reducing M1 responses and pro-inflammatory cytokines. In vitro co-culture experiments showed increased inflammation-resolving functions, including autophagy, phagocytosis, and production of specialized pro-resolving mediators. In a ligature-induced periodontitis mouse model, adoptive transfer of B10 cells reduced periodontal bone loss and enhanced macrophage-mediated resolution in gingival tissues. Depleting macrophages diminished these protective effects, confirming their key role. The talk concluded that B10–macrophage interactions promote resolution of periodontal inflammation and may offer therapeutic potential for periodontitis and peri-implantitis.

Meta Tag

Date April 16, 2026 1:30 PM - 1:45 PM

Room 156

Session Humoral-innate Immune Crosstalk

Speaker Xiaozhe Han

Track Immune Response Regulation: Cellular Mechanisms (IRC)

Year 2026

Keywords

regulatory B cells

B10 cells

periodontal inflammation

macrophage polarization

periodontitis therapy

April 16, 2026 1:30 PM - 1:45 PM

156

Humoral-innate Immune Crosstalk

Xiaozhe Han

Immune Response Regulation: Cellular Mechanisms (IRC)

2026