IMMUNOLOGY2026™ Conference Recordings For Attendees-Regulatory T Cell-Derived Amphiregulin Consolidates Transplant Tolerance via EGFR-Mediated T Cell Exhaustion

Regulatory T Cell-Derived Amphiregulin Consolidates Transplant Tolerance via EGFR-Mediated T Cell Exhaustion

Video Transcription

Video Summary

The speaker described a non-chimeric donor-cell tolerance strategy using ECDI-fixed donor leukocytes given before and after transplant, avoiding toxic immunosuppression. In nonhuman primate islet transplants, this approach produced long-term graft survival and stable function. Single-cell and spatial analyses showed expanded, highly suppressive, donor-specific Tregs in the spleen, along with exhausted CD8 T cells. The AREG–EGFR pathway was identified as a key mechanism: Treg-derived amphiregulin suppressed CD8 proliferation, cytokine production, and effector metabolism, shifting cells toward a tolerogenic state and supporting graft acceptance.

Meta Tag

Date April 17, 2026 2:00 PM - 2:15 PM

Room 156

Session Trouble with the Ex: exTregs and Beyond

Speaker Amar Singh

Track Immune Response Regulation: Cellular Mechanisms (IRC)

Year 2026

Keywords

donor-cell tolerance

ECDI-fixed donor leukocytes

nonhuman primate islet transplant

regulatory T cells

AREG-EGFR pathway

April 17, 2026 2:00 PM - 2:15 PM

156

Trouble with the Ex: exTregs and Beyond

Amar Singh

Immune Response Regulation: Cellular Mechanisms (IRC)

2026