IMMUNOLOGY2026™ Conference Recordings For Attendees-Regulatory T cells turn into multiple pro-inflammatory effector T cells in Mice with Atherosclerosis

Regulatory T cells turn into multiple pro-inflammatory effector T cells in Mice with Atherosclerosis

Video Transcription

Video Summary

The speaker presented a study on how regulatory T cells (Tregs) change in atherosclerosis, an inflammatory plaque-forming disease. Using lineage-tracing mice, diet-induced atherosclerosis, flow cytometry, single-cell RNA/TCR sequencing, and trajectory analysis, the team found Tregs become progressively destabilized and can turn into heterogeneous “ex-Treg” populations. These ex-Tregs showed effector-like, inflammatory programs, expanded clonally, and followed a branched differentiation path. The findings suggest Treg instability in atherosclerosis is structured and antigen-driven, with multiple pathways leading to diverse pro-inflammatory T-cell states.

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Date April 17, 2026 12:45 PM - 1:00 PM

Room 156

Session Trouble with the Ex: exTregs and Beyond

Speaker Qingkang Lyu

Track Immune Response Regulation: Cellular Mechanisms (IRC)

Year 2026

Keywords

regulatory T cells

atherosclerosis

Treg instability

single-cell RNA sequencing

inflammatory T-cell states

April 17, 2026 12:45 PM - 1:00 PM

156

Trouble with the Ex: exTregs and Beyond

Qingkang Lyu

Immune Response Regulation: Cellular Mechanisms (IRC)

2026