IMMUNOLOGY2026™ Conference Recordings For Attendees-Regulatory maturation of cDC1 accelerates effector CD8 T cell contraction after severe influenza A virus infection.

Regulatory maturation of cDC1 accelerates effector CD8 T cell contraction after severe influenza A virus infection.

Video Transcription

Video Summary

Dr. Xinran Wang presented research showing that CDC1 dendritic cells undergo functional changes during influenza A infection. While CDC1 are well known for priming CD8 T cells early in infection, Wang found that mature CDC1 persist into the resolution phase and become “regulatory” rather than activating. These late-stage CDC1 still present antigen, but they poorly induce interferon-gamma and instead drive a different CD8 T-cell program, including reduced T-bet and increased markers linked to tissue residency. Transcriptomic analysis showed the resolution-phase CDC1 have a distinct gene signature, including enrichment of efferocytosis-related pathways. In vivo bone marrow chimera experiments confirmed these CDC1 more efficiently engulf apoptotic cells during resolution. Overall, the study suggests that CDC1 shift from inflammatory antigen-presenting cells to regulatory, apoptotic-cell-clearing cells, altering the fate of CD8 T cells after severe influenza infection.

Meta Tag

Date April 16, 2026 1:45 PM - 2:00 PM

Room 104AB

Session CD8+ T Cell and NK Cell Mediated Antiviral Immunity

Speaker Xinran Wang

Track Viral Immunology (VIR)

Year 2026

Keywords

CDC1 dendritic cells

influenza A infection

CD8 T-cell priming

regulatory dendritic cells

efferocytosis

April 16, 2026 1:45 PM - 2:00 PM

104AB

CD8+ T Cell and NK Cell Mediated Antiviral Immunity

Xinran Wang

Viral Immunology (VIR)

2026