IMMUNOLOGY2026™ Conference Recordings For Attendees-Revealing NMOSD Molecular Mechanisms in an AQP4-Induced Animal Model

Revealing NMOSD Molecular Mechanisms in an AQP4-Induced Animal Model

Video Transcription

Video Summary

Gabriel Arellano described a mouse model of NMOSD, an autoimmune disease targeting the spinal cord and optic nerve. By immunizing mice with an aquaporin-4 peptide and blocking interferon-gamma signaling, his team created a severe, chronic disease that mirrors human NMOSD, including astrocyte loss, IgG/complement deposition, and immune-cell infiltration. They showed disease requires antigen-specific CD4 T cells, B cells, autoantibodies, and complement, while interferon-gamma is protective. STAT1, especially through type I interferon signaling, appears pathogenic. Single-cell RNA-seq further confirmed the model resembles patient disease.

Meta Tag

Date April 16, 2026 9:00 AM - 9:15 AM

Room 104AB

Session Cellular & Molecular Mechanisms of Autoreactivity

Speaker Gabriel Arellano

Track Basic Autoimmunity (BA)

Year 2026

Keywords

NMOSD

aquaporin-4

astrocyte loss

interferon-gamma

STAT1

April 16, 2026 9:00 AM - 9:15 AM

104AB

Cellular & Molecular Mechanisms of Autoreactivity

Gabriel Arellano

Basic Autoimmunity (BA)

2026