IMMUNOLOGY2026™ Conference Recordings For Attendees-Rewriting Autoimmunity: New Immunologic Insights Transforming T1D Therapy Development, Sponsored by Breakthrough T1D-3

Rewriting Autoimmunity: New Immunologic Insights Transforming T1D Therapy Development, Sponsored by Breakthrough T1D-3

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Video Summary

Dr. Jacqueline Nestor described building a 40-million-cell blood immune atlas from over 5,000 samples across 40 disease conditions, including autoimmune, infectious, and checkpoint inhibitor toxicity cases. Using single-cell RNA, protein, and TCR data, her team optimized integration and identified shared and disease-specific immune cell states. Preliminary findings showed known biology, like recent thymic immigrant CD4 T cells being more common in children, and revealed cytotoxic T cell subsets enriched in diseases such as lupus, diabetes, and celiac disease. Autoimmune risk variants were also most active in these cytotoxic cells, suggesting common mechanisms across autoimmune disorders.

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Date April 16, 2026 7:00 AM - 8:00 AM

Room 151

Session Rewriting Autoimmunity: New Immunologic Insights Transforming T1D Therapy Development

Speaker Jacquelyn Nestor

Track Basic Autoimmunity (BA)

Year 2026

Keywords

immune atlas

single-cell RNA

autoimmune diseases

cytotoxic T cells

TCR data

April 16, 2026 7:00 AM - 8:00 AM

151

Rewriting Autoimmunity: New Immunologic Insights Transforming T1D Therapy Development

Jacquelyn Nestor

Basic Autoimmunity (BA)

2026