IMMUNOLOGY2026™ Conference Recordings For Attendees-Role of B cell activation through Toll-like receptors in Systemic Lupus Erythematosus.

Role of B cell activation through Toll-like receptors in Systemic Lupus Erythematosus.

Video Transcription

Video Summary

Rodrigo’s research examines how TLR7 and TLR9 activation shapes B-cell fate in systemic lupus erythematosus (SLE). He focuses on naïve B cells and the expanded double-negative 2 (DN2) population, which is linked to autoreactive, antibody-secreting cells. His lab found that TLR7 promotes DN2 and plasmablast expansion, while TLR9 can expand DN2 cells even more strongly in some cultures and may restrain plasmablast/plasma cell differentiation in tonsil organoids. Using flow cytometry and single-cell RNA sequencing, the team hopes to define these pathways and assess TLR9 as a potential therapeutic target in SLE.

Meta Tag

Date April 17, 2026 1:15 PM - 1:30 PM

Room Ballroom

Session Inflammatory Mechanisms in Systemic Autoimmunity

Speaker Rodrigo Cervantes

Track Basic Autoimmunity (BA)

Year 2026

Keywords

Systemic lupus erythematosus

TLR7

TLR9

DN2 B cells

Plasmablast differentiation

April 17, 2026 1:15 PM - 1:30 PM

Ballroom

Inflammatory Mechanisms in Systemic Autoimmunity

Rodrigo Cervantes

Basic Autoimmunity (BA)

2026