IMMUNOLOGY2026™ Conference Recordings For Attendees-Role of Microbial Tryptophan Metabolism in Th17 Activation and Multiple Sclerosis

Role of Microbial Tryptophan Metabolism in Th17 Activation and Multiple Sclerosis

Video Transcription

Video Summary

Kate Stack studies how gut microbial tryptophan metabolism affects Th17 cells and multiple sclerosis. She showed that Lactobacillus ruteri produces indolelactate (ILA), a metabolite that helps suppress Th17 activation in vitro and reduces EAE disease severity in mice. An ILA-deficient strain was less protective, indicating ILA is important for full benefit. She also found that 1,3-butanediol increases beta-hydroxybutyrate levels and, when given before disease onset, lowers EAE scores and reduces pathogenic CNS T-cell responses. Overall, microbial metabolites and ketone-related diets may offer new strategies to reduce MS-related inflammation.

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Date April 17, 2026 1:45 PM - 2:00 PM

Room 153AB

Session T Cell Responses to the Gut Microbiota

Speaker Kate Stack

Track Mucosal And Regional Immunology (MUC)

Year 2026

Keywords

gut microbial tryptophan metabolism

Th17 cells

multiple sclerosis

indolelactate

beta-hydroxybutyrate

April 17, 2026 1:45 PM - 2:00 PM

153AB

T Cell Responses to the Gut Microbiota

Kate Stack

Mucosal And Regional Immunology (MUC)

2026