IMMUNOLOGY2026™ Conference Recordings For Attendees-Sepsis-induced alterations to the microenvironment promotes maladaptive emergency granulopoiesis and susceptibility to Streptococcus pneumoniae

Sepsis-induced alterations to the microenvironment promotes maladaptive emergency granulopoiesis and susceptibility to Streptococcus pneumoniae

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Video Summary

The speaker discusses post-sepsis syndrome and why survivors remain highly vulnerable to later infections. Using a mouse cecal ligation and puncture model, they show that even after apparent recovery, mice die more often after secondary Streptococcus pneumoniae challenge. The problem is not the bone marrow alone, since transplanted sepsis-derived hematopoietic cells function normally in a healthy host. Instead, the post-sepsis microenvironment, especially the bone marrow niche and endothelium, drives abnormal emergency granulopoiesis and excessive immature neutrophils. Single-cell RNA-seq shows activated, cytokine-responsive endothelial changes that likely imprint long-term immune dysfunction and infection susceptibility.

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Date April 18, 2026 12:45 PM - 1:00 PM

Room 156

Session Microenvironmental Influences on Innate Immunity

Speaker Amber Bahr

Track Innate Immune Responses and Host Defense: Cellular Mechanisms (INC)

Year 2026

Keywords

post-sepsis syndrome

secondary infection susceptibility

emergency granulopoiesis

bone marrow niche

endothelial dysfunction

April 18, 2026 12:45 PM - 1:00 PM

156

Microenvironmental Influences on Innate Immunity

Amber Bahr

Innate Immune Responses and Host Defense: Cellular Mechanisms (INC)

2026