IMMUNOLOGY2026™ Conference Recordings For Attendees-Sequential interactions with distinct DC subsets direct CD4 T helper cell differentiation

Sequential interactions with distinct DC subsets direct CD4 T helper cell differentiation

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Video Summary

The speaker presented work on how different skin dendritic cell (DC) subsets control CD4 T cell fate. In the draining lymph node, CD11b+ DCs near the T cell zone/HEV prime incoming naive CD4 T cells earlier than other DCs. Using synchronized priming models, the study showed two waves of TCR signaling: CD11b+ DCs initiate the first wave, while CD207+ DCs, likely cDC1s, contribute later. Sustained interaction with CD11b+ DCs was essential for Th2 differentiation, whereas later interaction with CD207+ DCs was needed for Th1 differentiation. Single-cell RNA sequencing revealed a shared early activation stage followed by divergent Th2 or Th1 precursor programs. The CCR17–CCR4 pathway promoted sustained CD11b+ DC–T cell contact and specifically supported Th2 fate. Overall, the work proposes a sequential model in which distinct DC subsets temporally imprint helper T cell differentiation.

Meta Tag

Date April 19, 2026 8:15 AM - 8:30 AM

Room 153AB

Session Dynamic Control of T Cell Activation

Speaker Naoya Tatsumi

Track Immune Response Regulation: Cellular Mechanisms (IRC)

Year 2026

Keywords

skin dendritic cells

CD4 T cell fate

TCR signaling

Th1 differentiation

Th2 differentiation

April 19, 2026 8:15 AM - 8:30 AM

153AB

Dynamic Control of T Cell Activation

Naoya Tatsumi

Immune Response Regulation: Cellular Mechanisms (IRC)

2026