IMMUNOLOGY2026™ Conference Recordings For Attendees-Signaling dynamics in cytokine-driven gene control

Video Transcription

Video Summary

The speaker thanked the Cytokine Society and promoted an upcoming cytokine biology meeting before presenting research on how cytokine signals drive context-specific gene programs in macrophages. Her lab studies how STAT signaling and cooperating pathways decode cytokine cues to shift macrophages through inflammatory, anti-inflammatory, and wound-healing states. She highlighted prior work using computational modeling to predict how JAK2 perturbation affects signaling dynamics and gene expression. The main focus was a collaboration profiling IL-6 and IL-10 responses in mouse bone marrow-derived macrophages with phosphoproteomics and RNA-seq. Using multiple computational filters, they prioritized phosphorylation sites on transcription factors, then used base editing in primary macrophages to perturb candidate residues, starting with STAT3 as a proof of concept. They also discussed mapping upstream kinases and building causal signaling networks to identify targetable pathways that shape specific cytokine-driven gene programs, especially in inflammation and disease.

Meta Tag

Date April 17, 2026 9:45 AM - 11:15 AM

Room 151

Session Translating Human Immunology Through Cytokine Research, Sponsored by the Intl. Cytokine and Interferon Soc. (ICIS)

Speaker Rachel Gottschalk

Track Cytokines and Chemokines and their Receptors (CCR)

Year 2026

Keywords

cytokine signaling

macrophages

STAT3

phosphoproteomics

RNA-seq

April 17, 2026 9:45 AM - 11:15 AM

151

Translating Human Immunology Through Cytokine Research, Sponsored by the Intl. Cytokine and Interferon Soc. (ICIS)

Rachel Gottschalk

Cytokines and Chemokines and their Receptors (CCR)

2026