IMMUNOLOGY2026™ Conference Recordings For Attendees-Signaling pathways via BAFF receptor/Nav1.7 channel contribute to the activation of monocytes and B cells in patients with Sjögren's disease.

Signaling pathways via BAFF receptor/Nav1.7 channel contribute to the activation of monocytes and B cells in patients with Sjögren's disease.

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Video Summary

Keiko Yoshimoto presented findings on Sjögren’s disease showing that BAFF/BR3 signaling and the sodium channel NaV1.7 contribute to monocyte and B-cell activation. In patients, BR3 and NaV1.7 expression was elevated in monocytes, and NaV1.7 also correlated with BR3 in B cells. BAFF stimulation increased NaV1.7, IL-6, and IgG production, while a NaV1.7 inhibitor reduced both IL-6 from monocytes and IgG from B cells. The study suggests BAFF–BR3–NaV1.7 crosstalk may be a novel therapeutic target for Sjögren’s disease.

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Date April 18, 2026 1:45 PM - 1:57 PM

Room 153AB

Session Pathophysiology of Cytokines and Chemokines

Speaker Keiko Yoshimoto

Track Cytokines and Chemokines and their Receptors (CCR)

Year 2026

Keywords

Sjögren’s disease

BAFF/BR3 signaling

NaV1.7

monocyte activation

B-cell activation

April 18, 2026 1:45 PM - 1:57 PM

153AB

Pathophysiology of Cytokines and Chemokines

Keiko Yoshimoto

Cytokines and Chemokines and their Receptors (CCR)

2026