IMMUNOLOGY2026™ Conference Recordings For Attendees-Single Cell Insights on Inflammation-Induced Transitional States in Benign Prostate Hyperplasia

Single Cell Insights on Inflammation-Induced Transitional States in Benign Prostate Hyperplasia

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Video Summary

The speaker presented research on benign prostatic hyperplasia (BPH), focusing on how inflammation may drive prostate enlargement through transitional epithelial states. Using single-cell RNA sequencing in mouse models and human prostate samples, the team identified a cluster of cells co-expressing basal, luminal, and transitional markers, especially KRT19. This transitional population showed elevated androgen receptor activity and inflammatory signaling, and it correlated across mouse and human data. The study suggests inflammation induces a shared transitional cell state that may contribute to BPH. Future work will trace the origin of these cells and search for similar populations in other datasets.

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Date April 16, 2026 10:15 AM - 10:30 AM

Room 156

Session Understanding Immune Responses to Optimize Immune Intervention

Speaker Nikhila T. Suresh

Track Translational and Interventional Immunology (TI)

Year 2026

Keywords

benign prostatic hyperplasia

inflammation

transitional epithelial cells

single-cell RNA sequencing

KRT19

April 16, 2026 10:15 AM - 10:30 AM

156

Understanding Immune Responses to Optimize Immune Intervention

Nikhila T. Suresh

Translational and Interventional Immunology (TI)

2026