IMMUNOLOGY2026™ Conference Recordings For Attendees-Single-cell mapping of stress-conditioned hematopoiesis reveals distinct molecular adaptation separating resilience from susceptibility

Single-cell mapping of stress-conditioned hematopoiesis reveals distinct molecular adaptation separating resilience from susceptibility

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Video Summary

The speaker discussed how “memory” in non-immune somatic cells may be encoded, focusing on hematopoiesis, a highly dynamic and diverse system. Using chronic stress models in mice—social isolation and chronic social defeat stress—they examined bone marrow and related tissues to see how stress affects blood cell development. Single-cell RNA and ATAC sequencing showed that stress expands myeloid cell programs while reducing erythroid fate, and that these changes appear in both resilient and susceptible mice. However, resilient mice showed a coordinated, organized response across hematopoietic hierarchies, while susceptible mice had fragmented responses. The team identified conserved gene and chromatin programs, including stress-response and metabolic pathways in resilience, and inflammatory programs in susceptibility. They also found transcription factors linked to stress buffering and loss of stem cell identity in susceptible mice. Overall, the study suggests chronic stress leaves an epigenetic memory in bone marrow cells that may influence disease risk and therapy response.

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Date April 16, 2026 5:15 PM - 5:30 PM

Room 104AB

Session Bone Marrow Hematopoiesis

Speaker Indranil Singh

Track Hematopoiesis and Immune System Development (HEM)

Year 2026

Keywords

hematopoiesis

chronic stress

epigenetic memory

single-cell RNA sequencing

myeloid differentiation

April 16, 2026 5:15 PM - 5:30 PM

104AB

Bone Marrow Hematopoiesis

Indranil Singh

Hematopoiesis and Immune System Development (HEM)

2026