IMMUNOLOGY2026™ Conference Recordings For Attendees-Skeletal muscle as an active immune niche orchestrating adaptive responses to replicon RNA vaccination

Skeletal muscle as an active immune niche orchestrating adaptive responses to replicon RNA vaccination

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Video Summary

Taishi Kimura of HDT Bio described Lion, a cationic RNA delivery system that binds RNA on its surface and appears better tolerated than lipid nanoparticles. Using localized RepRNA vaccination in mice, the team found that muscle becomes an active immune niche, recruiting CXCR5+ CD4 T cells and B cells. CD4 T cells were required for antibody responses, and plasmablasts expanded mainly in muscle. Early responses depended partly on IL-21 and germinal centers, but later antibody production persisted without them. Blocking lymphocyte trafficking had little effect, showing localized intramuscular RepRNA can drive antibody immunity independently of continuous lymph node recirculation.

Meta Tag

Date April 16, 2026 2:00 PM - 2:15 PM

Room 156

Session Humoral-innate Immune Crosstalk

Speaker Taishi Kimura

Track Immune Response Regulation: Cellular Mechanisms (IRC)

Year 2026

Keywords

cationic RNA delivery

localized RepRNA vaccination

muscle immune niche

CXCR5+ CD4 T cells

antibody immunity

April 16, 2026 2:00 PM - 2:15 PM

156

Humoral-innate Immune Crosstalk

Taishi Kimura

Immune Response Regulation: Cellular Mechanisms (IRC)

2026