IMMUNOLOGY2026™ Conference Recordings For Attendees-Spatial IgA Plasma Cell Niches Drive Anti-Tumor Immunity in Pancreatic Cancer

Spatial IgA Plasma Cell Niches Drive Anti-Tumor Immunity in Pancreatic Cancer

Video Transcription

Video Summary

This talk examined spatial niches of IgA/IgM versus IgG plasma cells in pancreatic ductal adenocarcinoma (PDAC), a highly lethal cancer with poor survival and strong stromal barriers to therapy. Using 71 patient spatial transcriptomics datasets plus matched single-cell and TCR-seq data, the speaker found two distinct niches: IgA/IgM plasma cells were enriched with T cells, NK cells, and myeloid cells, while IgG plasma cells clustered separately. Higher IgA/IgM-to-IgG abundance was associated with better patient survival in TCGA and supported by spatial data.<br /><br />Functional analyses suggested the IgA/IgM niche promotes immune activation: nearby myeloid cells showed enhanced antigen presentation and cross-presentation, T/NK cells showed stronger TCR and interferon signaling, and T cells in these niches had greater clonal expansion. Candidate ligand-receptor interactions included ICAM2-integrin and CCL14-CCL4. The transcript also proposed LY1 as a potential activator of BCR signaling and downstream MAF/IR4 programs in plasma cells.

Meta Tag

Date April 16, 2026 8:45 AM - 9:00 AM

Room 157

Session T Cells in Cancer II

Speaker Lily Liu

Track Tumor Immunology: Cellular Responses and Tumor Microenvironment (TIME)

Year 2026

Keywords

pancreatic ductal adenocarcinoma

IgA/IgM plasma cells

IgG plasma cells

spatial transcriptomics

immune activation

April 16, 2026 8:45 AM - 9:00 AM

157

T Cells in Cancer II

Lily Liu

Tumor Immunology: Cellular Responses and Tumor Microenvironment (TIME)

2026