IMMUNOLOGY2026™ Conference Recordings For Attendees-Spatial stochasticity in lymph node microdomains optimizes host protection and enforces self-tolerance

Spatial stochasticity in lymph node microdomains optimizes host protection and enforces self-tolerance

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Video Summary

The speaker presents research on regulatory T cells (Tregs), which are usually thought to prevent autoimmunity by recognizing self-antigens. He shows that Tregs can also respond strongly to foreign antigens, often more strongly than conventional T cells. Using reporter mice, tetramers, and lymph node imaging after bacterial immunization, he finds that Tregs are enriched among highly reactive cells and form local clusters with T cells. He proposes “special stochasticity”: local, random competition in lymph nodes lets Tregs suppress weak clones while allowing the strongest foreign-reactive T cells to expand, thereby optimizing immune responses during infection.

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Date April 19, 2026 8:00 AM - 8:13 AM

Room 102

Session Development of Statistical, Machine Learning, and Genetic Models

Speaker Tomer Milo

Track Computational and Systems Immunology (COMP)

Year 2026

Keywords

regulatory T cells

foreign antigens

tetramer imaging

lymph node clusters

special stochasticity

April 19, 2026 8:00 AM - 8:13 AM

102

Development of Statistical, Machine Learning, and Genetic Models

Tomer Milo

Computational and Systems Immunology (COMP)

2026