IMMUNOLOGY2026™ Conference Recordings For Attendees-Spatio-temporal mapping of immune cell dynamics during human sequential lymph node metastasis

Spatio-temporal mapping of immune cell dynamics during human sequential lymph node metastasis

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Video Summary

Cheng, a Cambridge PhD candidate, presented research on human lymph node metastasis in triple-negative breast cancer. Using sentinel and secondary lymph nodes from 15 treatment-naive patients, the team built a single-cell and spatial immune atlas from CD45+ cells. They found progressive loss of dendritic cells, especially CD1C+ cDC2s, and NK cells, alongside expansion of immunosuppressive macrophages. CD1C+ cDC2 abundance in lymph nodes predicted better response and longer event-free survival in anti-PD1-treated patients. Machine-learning analyses and mouse studies suggested that combining anti-MARCO with PD-1 blockade may improve tumor control.

Meta Tag

Date April 19, 2026 10:30 AM - 10:45 AM

Room 156

Session Immune Cells in the Tumor Microenvironment III

Speaker Qiuchen Zhao

Track Tumor Immunology: Cellular Responses and Tumor Microenvironment (TIME)

Year 2026

Keywords

triple-negative breast cancer

lymph node metastasis

single-cell immune atlas

CD1C+ cDC2 dendritic cells

anti-MARCO and PD-1 blockade

April 19, 2026 10:30 AM - 10:45 AM

156

Immune Cells in the Tumor Microenvironment III

Qiuchen Zhao

Tumor Immunology: Cellular Responses and Tumor Microenvironment (TIME)

2026