IMMUNOLOGY2026™ Conference Recordings For Attendees-Steady-state immune surveillance of the nasal mucosa by neutrophils

Steady-state immune surveillance of the nasal mucosa by neutrophils

Video Transcription

Video Summary

The talk describes how the mouse nasal mucosa contains three distinct neutrophil populations. N1 cells appear to originate locally from bone marrow pockets connected to the nasal mucosa by conduits, and they can enter the mucosa when homeostasis is disrupted. N2 cells come from blood and are the main phagocytic neutrophils, efficiently engulfing pathogens such as Candida albicans, Streptococcus pneumoniae, and Chlamydia. Under steady-state conditions, some N2 cells mature into N3 cells only in the nose. N3 neutrophils adopt a more dendritic-like shape, acquire material from neighboring cells, and can present antigen to CD8 T cells, suggesting an APC-like role. Overall, the study shows that the nose is not just a barrier, but a site of specialized and dynamic neutrophil surveillance with distinct origins, phenotypes, and functions.

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Date April 19, 2026 10:30 AM - 10:45 AM

Room 104 AB

Session Innate Defenses against Pathogens

Speaker Rodrigo Gonzalez

Track Innate Immune Responses and Host Defense: Cellular Mechanisms (INC)

Year 2026

Keywords

mouse nasal mucosa

neutrophil populations

phagocytic neutrophils

antigen presentation

nasal immune surveillance

April 19, 2026 10:30 AM - 10:45 AM

104 AB

Innate Defenses against Pathogens

Rodrigo Gonzalez

Innate Immune Responses and Host Defense: Cellular Mechanisms (INC)

2026