IMMUNOLOGY2026™ Conference Recordings For Attendees-Stem-like and effector peripheral helper T cells orchestrate distinct local immune responses in rheumatoid arthritis

Stem-like and effector peripheral helper T cells orchestrate distinct local immune responses in rheumatoid arthritis

Video Transcription

Video Summary

The talk presented new insights into peripheral helper T cells (TPH) in rheumatoid arthritis. Using patient synovial tissue, fluid, and blood, researchers identified two TPH subsets: stem-like TPH (STPH) and effector TPH (eTPH). STPH cells were CCR7-positive, highly proliferative, self-renewing, and could differentiate into eTPH cells. STPH cells localized with B cells in tertiary lymphoid structures, likely recruited by CCR19+ fibroblast-like synovial cells, and promoted IgG production. eTPH cells were linked with macrophages, CD8 T cells, and tissue inflammation. TPH-derived IGFL-2 activated monocytes/macrophages, suggesting TPH cells drive chronic RA inflammation beyond B-cell help.

Meta Tag

Date April 15, 2026 4:30 PM - 4:45 PM

Room 157

Session Orchestration of the Adaptive Immune Response

Speaker Yuki Masuo

Track Immune Mechanisms of Human Disease (HUM)

Year 2026

Keywords

peripheral helper T cells

rheumatoid arthritis

stem-like TPH

effector TPH

tertiary lymphoid structures

April 15, 2026 4:30 PM - 4:45 PM

157

Orchestration of the Adaptive Immune Response

Yuki Masuo

Immune Mechanisms of Human Disease (HUM)

2026