IMMUNOLOGY2026™ Conference Recordings For Attendees-Strain-specific variation drives CD8+ T cell activation responses

Strain-specific variation drives CD8+ T cell activation responses

Video Transcription

Video Summary

The talk explored how genetic diversity across mouse strains affects CD8 T-cell activation, including TCR-dependent and bystander, cytokine-driven responses. Using single-cell RNA-seq on eight diverse strains, the speaker found major strain-specific differences in virtual memory cell proportions, activation behavior, and gene expression. Black6 mice were unusually responsive, while wild-derived strains showed distinct patterns. Candidate genes included TNF family members, Jun, and TRIM12A/TRIM34A, with a Black6-specific enhancer-like locus possibly driving expression. Data from Diversity Outbred mice and GWAS further linked IL-18 receptor expression to responsiveness. Overall, genetics, developmental origin, and cell state shape CD8 T-cell function.

Meta Tag

Date April 15, 2026 4:00 PM - 4:15 PM

Room 151

Session Immunological -omics Analysis

Speaker Jason Chobirko

Track Computational and Systems Immunology (COMP)

Year 2026

Keywords

CD8 T-cell activation

genetic diversity

single-cell RNA-seq

virtual memory cells

IL-18 receptor

April 15, 2026 4:00 PM - 4:15 PM

151

Immunological -omics Analysis

Jason Chobirko

Computational and Systems Immunology (COMP)

2026