IMMUNOLOGY2026™ Conference Recordings For Attendees-Systemic CXCL13 as a possible sex-dependent biomarker to identify neuroinflammation in subclinical food allergies

Systemic CXCL13 as a possible sex-dependent biomarker to identify neuroinflammation in subclinical food allergies

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Video Summary

The talk described nine major food allergens and focused on a milk allergy mouse model of subclinical sensitization, where mice developed allergen-specific IgE without obvious clinical symptoms. Male mice showed stronger effects than females: increased IgE, reduced exploratory and cognitive behavior, more microglia, and decreased myelin. The study implicated the CXCL13-CXCR5 chemokine pathway in immune cell migration to the brain and dura, with CXCL13 elevated in male mice and correlated with IgE and CXCR5-positive cells. The speaker proposed CXCL13 as a sex-specific biomarker for food allergy-related neuroinflammation and is validating it in human samples.

Meta Tag

Date April 18, 2026 12:45 PM - 1:00 PM

Room 253

Session Peripheral & Central Neuroimmune Interactions

Speaker Dilini Ekanayake

Track Neuroimmunology (NEUR)

Year 2026

Keywords

food allergy

milk allergy

subclinical sensitization

CXCL13-CXCR5 pathway

neuroinflammation

April 18, 2026 12:45 PM - 1:00 PM

253

Peripheral & Central Neuroimmune Interactions

Dilini Ekanayake

Neuroimmunology (NEUR)

2026