IMMUNOLOGY2026™ Conference Recordings For Attendees-T Cell-Specific Deletion of Glutaminase (Gls1) Lowers AutoAb Production in Lupus Mice by Altering Metabolism and Function of Follicular Helper T Cells

T Cell-Specific Deletion of Glutaminase (Gls1) Lowers AutoAb Production in Lupus Mice by Altering Metabolism and Function of Follicular Helper T Cells

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Video Summary

The talk described lupus as an autoimmune disease driven by hyperactive TFH cells that help B cells produce pathogenic autoantibodies. The speaker showed that inhibiting glutamine metabolism with DON, or deleting T cell GLS1, did not stop TFH differentiation but severely reduced TFH function, especially ICOS expression, germinal center size, and anti-dsDNA antibodies. Autoreactive T cells were uniquely dependent on glutamine for metabolic fitness. Mechanistic studies suggested ICOS is not controlled by transcription, proteasomal degradation, or internalization, pointing to a novel post-translational, proteostasis-based pathway linking glutamine metabolism to TFH dysfunction in lupus.

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Date April 16, 2026 3:45 PM - 4:00 PM

Room 253

Session Immunometabolism in Autoimmunity

Speaker Milind Joshi

Track Basic Autoimmunity (BA)

Year 2026

Keywords

lupus

TFH cells

glutamine metabolism

ICOS expression

autoantibodies

April 16, 2026 3:45 PM - 4:00 PM

253

Immunometabolism in Autoimmunity

Milind Joshi

Basic Autoimmunity (BA)

2026