IMMUNOLOGY2026™ Conference Recordings For Attendees-T cell dysfunction during Staphylococcus aureus osteomyelitis in humanized mice

T cell dysfunction during Staphylococcus aureus osteomyelitis in humanized mice

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Video Summary

Researchers studied Staph aureus osteomyelitis, a costly bone infection that complicates joint replacement surgery and often recurs despite antibiotics and surgery. Using a humanized mouse tibial pin model, they found infection drives a Th1/Th17 CD4 T-cell response with signs of exhaustion: increased PD-1, Lag-3, and Tim-3, reduced proliferation, and lower cytokine production. These exhausted T-cell markers were also observed in infected human tissue. In patient serum, Tim-3 predicted poor outcomes such as reinfection, amputation, and septic death. The work suggests T-cell checkpoint markers may help diagnose disease severity and guide treatment.

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Date April 17, 2026 12:45 PM - 1:00 PM

Room 153C

Session Adaptive Immune Responses to Microbial Infections

Speaker Katya McDonald

Track Microbial, Parasitic, and Fungal Immunology (MPF)

Year 2026

Keywords

Staph aureus osteomyelitis

T-cell exhaustion

PD-1 Tim-3 Lag-3

humanized mouse model

infection prognosis

April 17, 2026 12:45 PM - 1:00 PM

153C

Adaptive Immune Responses to Microbial Infections

Katya McDonald

Microbial, Parasitic, and Fungal Immunology (MPF)

2026