IMMUNOLOGY2026™ Conference Recordings For Attendees-TRIM21 Orchestrates Inflammasome Assembly and Drives Autoinflammatory Pathology.

TRIM21 Orchestrates Inflammasome Assembly and Drives Autoinflammatory Pathology.

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Video Summary

The speaker described research showing that TRIM21 promotes inflammasome activation by binding ASC, ubiquitinating it, and enabling ASC speck formation, polymerization, and caspase-1 activation. TRIM21 knockout cells had reduced IL-1β, IL-18, gasdermin cleavage, and pyroptotic death, while in mice TRIM21 deficiency rescued autoinflammatory disease phenotypes. TRIM21 was also found in released ASC specks and elevated in CAPS and FMF patient samples, along with anti-TRIM21 autoantibodies. Overall, TRIM21 appears to drive autoinflammatory pathology and may link autoimmune and autoinflammatory disease mechanisms.

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Date April 16, 2026 4:57 PM - 5:09 PM

Room 156

Session Pathogen Sensing and Innate Immune Responses

Speaker Jessica Carriere

Track Innate Immune Responses and Host Defense: Molecular Mechanisms (INM)

Year 2026

Keywords

TRIM21

inflammasome activation

ASC specks

autoinflammatory disease

caspase-1

April 16, 2026 4:57 PM - 5:09 PM

156

Pathogen Sensing and Innate Immune Responses

Jessica Carriere

Innate Immune Responses and Host Defense: Molecular Mechanisms (INM)

2026