IMMUNOLOGY2026™ Conference Recordings For Attendees-Targeting convergent pathways prevents the differentiation of tissue-resident memory T cells from multilineage progenitors in the arthritic synovium

Targeting convergent pathways prevents the differentiation of tissue-resident memory T cells from multilineage progenitors in the arthritic synovium

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Video Summary

The speaker describes how tissue-resident memory CD8 T cells (TRM) help explain “joint-specific memory” in rheumatoid arthritis and juvenile idiopathic arthritis, where flares often recur in previously inflamed joints. Using mouse arthritis models and a human 3D synovial organoid system, the study shows TRM persist during remission and can arise from both central memory and effector memory T cells. Single-cell and lineage analyses identified shared differentiation pathways, including RUNX3 signaling. Antisense oligonucleotides targeting RUNX3 reduced TRM formation in both human organoids and mice, suggesting a potential new therapy for chronic arthritis.

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Date April 16, 2026 1:30 PM - 1:45 PM

Room 157

Session Homeostasis

Speaker Yang Yang

Track Lymphocyte Differentiation and Peripheral Maintenance (LYM)

Year 2026

Keywords

tissue-resident memory CD8 T cells

rheumatoid arthritis

juvenile idiopathic arthritis

RUNX3 signaling

synovial organoid model

April 16, 2026 1:30 PM - 1:45 PM

157

Homeostasis

Yang Yang

Lymphocyte Differentiation and Peripheral Maintenance (LYM)

2026