IMMUNOLOGY2026™ Conference Recordings For Attendees-Targeting genome organizer Satb1 in regulatory T cells safely and potently enhances cancer immunity

Targeting genome organizer Satb1 in regulatory T cells safely and potently enhances cancer immunity

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Video Summary

The speaker presented research on SABI-1/SAB1, a chromatin organizer in regulatory T cells (Tregs). Tregs normally maintain immune tolerance and suppress inflammation, but in cancer they can also promote tumor growth, making them difficult to target safely. The team discovered two Treg subtypes: SAB1-negative and SAB1-positive. SAB1-negative Tregs are common in lymphoid organs and support immune balance, while SAB1-positive Tregs are enriched in tumors and express suppressive markers like TIGIT, ICOS, and PD-1. <br /><br />Using Treg-specific SAB1 knockout mice, they found dramatic tumor rejection in multiple cancer models, including bladder cancer, melanoma, lung cancer, and glioblastoma, without triggering autoimmunity. The knockout Tregs still protected against colitis, showing that normal immune tolerance remained intact. The enhanced anti-tumor effect depended on CD8 T cells. They also identified PCVP1 as an upstream regulator of SAB1 in tumor Tregs.

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Date April 17, 2026 4:15 PM - 4:30 PM

Room 153AB

Session Cellular Responses and the Tumor Microenvironment

Speaker Ephraim Ansa-Addo

Track Tumor Immunology: Cellular Responses and Tumor Microenvironment (TIME)

Year 2026

Keywords

SABI-1/SAB1

regulatory T cells

tumor immunity

Treg subtypes

CD8 T cells

April 17, 2026 4:15 PM - 4:30 PM

153AB

Cellular Responses and the Tumor Microenvironment

Ephraim Ansa-Addo

Tumor Immunology: Cellular Responses and Tumor Microenvironment (TIME)

2026