IMMUNOLOGY2026™ Conference Recordings For Attendees-The Epstein-Barr virus-induced gene 2-Cholesterol 25-hydroxylase axis is essential for the recruitment of mast cell progenitors.

The Epstein-Barr virus-induced gene 2-Cholesterol 25-hydroxylase axis is essential for the recruitment of mast cell progenitors.

Back to course

Video Transcription

Video Summary

The talk described how mast cell progenitors are recruited into inflamed lungs during type 2 inflammatory disease. Using a house dust mite mouse model and human/mouse single-cell data, the speaker identified a conserved EBI2–CH25H axis: endothelial CH25H produces the EBI2 ligand, which attracts progenitor cells expressing EBI2. In vitro migration was blocked by an EBI2 inhibitor. In vivo, deleting CH25H or EBI2 prevented mast cell progenitor recruitment and expansion in lung tissue. The findings suggest mast cell maturation begins earlier than expected and may involve a vascular pre-maturation stage before tissue entry.

Meta Tag

Date April 18, 2026 10:45 AM - 11:00 AM

Room 151

Session Immediate Hypersensitivity

Speaker Hadas Tamar Pahima

Track Immediate Hypersensitivity, Asthma, and Allergic Responses (HYP)

Year 2026

Keywords

mast cell progenitors

type 2 inflammation

EBI2-CH25H axis

lung recruitment

house dust mite model

April 18, 2026 10:45 AM - 11:00 AM

151

Immediate Hypersensitivity

Hadas Tamar Pahima

Immediate Hypersensitivity, Asthma, and Allergic Responses (HYP)

2026