IMMUNOLOGY2026™ Conference Recordings For Attendees-The Ikaros zinc finger transcription factor Aiolos promotes the formation of lung-resident memory CD8+ T cells.

The Ikaros zinc finger transcription factor Aiolos promotes the formation of lung-resident memory CD8+ T cells.

Video Transcription

Video Summary

The speaker studied how the transcription factor ALOS affects lung resident memory CD8 T cells (TRM). Using OT1 mouse adoptive transfer and influenza infection, ALOS-deficient CD8 T cells showed fewer lung CD8 cells, fewer peripheral tissue cells, and fewer TRM at both early and memory stages. Mechanistically, ALOS appears to promote TRM by repressing EOMES, enhancing TGF-beta receptor 1 expression and SMAD2/3 signaling, and supporting memory precursor and TRM precursor formation. These findings suggest ALOS is important for lung immune memory and could be targeted to improve vaccines or reduce lung disease.

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Date April 16, 2026 2:00 PM - 2:15 PM

Room 157

Session Homeostasis

Speaker Gayathri Dileepan

Track Lymphocyte Differentiation and Peripheral Maintenance (LYM)

Year 2026

Keywords

ALOS

lung resident memory CD8 T cells

TRM

EOMES repression

TGF-beta SMAD signaling

April 16, 2026 2:00 PM - 2:15 PM

157

Homeostasis

Gayathri Dileepan

Lymphocyte Differentiation and Peripheral Maintenance (LYM)

2026