IMMUNOLOGY2026™ Conference Recordings For Attendees-The histone demethylase KDM5C orchestrates VGLL3 and TLR7 crosstalk to drive female-biased autoimmunity

The histone demethylase KDM5C orchestrates VGLL3 and TLR7 crosstalk to drive female-biased autoimmunity

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Video Summary

The talk described research into why autoimmune diseases are much more common in women. The speaker focused on the X chromosome, especially genes like TLR7 that can escape X-inactivation, and on Xist, a noncoding RNA linked to autoantibody binding. Their lab found that the transcription cofactor VGLL3, though not X-linked, is regulated by the X-linked histone demethylase KDM5C. VGLL3 is higher and more nuclear in female skin cells and strongly elevated in lupus skin. In mice, keratinocyte-specific VGLL3 expression caused skin inflammation and systemic autoimmunity. VGLL3 amplified TLR7-driven inflammation indirectly, likely through NEAT1 and extracellular vesicles, creating a feedforward loop. The study also linked KDM5C and VGLL3 in lupus and systemic sclerosis, suggesting a broader mechanism for female-biased autoimmunity.

Meta Tag

Date April 19, 2026 11:00 AM - 11:15 AM

Room 153 AB

Session Primary Immune Deficiency and Immune Dysregulation

Speaker Olesya Plazyo

Track Immune Mechanisms of Human Disease (HUM)

Year 2026

Keywords

autoimmune diseases

X chromosome

VGLL3

TLR7

lupus

April 19, 2026 11:00 AM - 11:15 AM

153 AB

Primary Immune Deficiency and Immune Dysregulation

Olesya Plazyo

Immune Mechanisms of Human Disease (HUM)

2026