IMMUNOLOGY2026™ Conference Recordings For Attendees-The impact of skin-like CD103+ ILC2s on lung immunity

Video Transcription

Video Summary

The talk described a study on tissue-resident group 2 innate lymphoid cells (ILC2s), focusing on a “skin-like” ILC2 subset marked by CD103/ITGAE and distinct from lung ILC2s. The speaker showed that demodex mite skin infection drives expansion of these skin-like ILC2s, which then leave the skin, enter the circulation, and accumulate in the lung, where they can adopt some lung-like features but retain a tissue-imprinted identity. This migration was confirmed using labeling, parabiosis, and cohousing experiments. The relocated ILC2s formed a persistent niche in the lung and altered immune responses during later helminth infection, reducing inflammation and tissue damage while changing type 2 and type 3 cytokine responses. The speaker suggested this represents an innate immune memory-like state shaped by skin inflammation, though the exact mechanism of egress remains unclear.

Meta Tag

Date April 15, 2026 4:00 PM - 4:15 PM

Room 102

Session Immunology of the Respiratory Tract

Speaker Mi Lian

Track Mucosal And Regional Immunology (MUC)

Year 2026

Keywords

tissue-resident ILC2

CD103 ITGAE

demodex mite infection

skin-to-lung migration

innate immune memory

helminth infection

April 15, 2026 4:00 PM - 4:15 PM

102

Immunology of the Respiratory Tract

Mi Lian

Mucosal And Regional Immunology (MUC)

2026