IMMUNOLOGY2026™ Conference Recordings For Attendees-The role of interferon-stimulated gene IFIT2 in a sex-dependent Treg modulation in CNS autoimmunity

The role of interferon-stimulated gene IFIT2 in a sex-dependent Treg modulation in CNS autoimmunity

Video Transcription

Video Summary

The talk examined how interferon-induced protein IFIT2 regulates Treg cells in experimental autoimmune encephalomyelitis, a model of multiple sclerosis. Treg-specific IFIT2 knockout mice had worse disease, especially males, with more CNS inflammation and cytokine-producing T cells. RNA-seq and metabolic studies showed IFIT2 supports interferon-beta-driven suppression of glycolysis and promotes PPARα expression, mainly in male Tregs. Loss of IFIT2 blocked these effects and weakened Treg function. Human data also suggested reduced interferon signaling in MS Tregs. Overall, IFIT2 links interferon signaling, metabolism, and sex-specific Treg control of autoimmune inflammation.

Meta Tag

Date April 17, 2026 1:30 PM - 1:45 PM

Room 156

Session Trouble with the Ex: exTregs and Beyond

Speaker MIJIN KIM

Track Immune Response Regulation: Cellular Mechanisms (IRC)

Year 2026

Keywords

IFIT2

Treg cells

multiple sclerosis

interferon signaling

autoimmune inflammation

April 17, 2026 1:30 PM - 1:45 PM

156

Trouble with the Ex: exTregs and Beyond

MIJIN KIM

Immune Response Regulation: Cellular Mechanisms (IRC)

2026